Journal of Yeungnam Medical Science
- 제11권2호
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- Pages.363-374
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- 1994
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- 2799-8010(eISSN)
흰쥐 배뇨근에 존재하는 potassium 통로의 특성
Characteristics of Potassium Channel in the Isolated Rat Detrusor Muscle
- 장명수 (영남대학교 의과대학 약리학교실) ;
- 최은미 (영남대학교 의과대학 약리학교실) ;
-
하정희
(영남대학교 의과대학 약리학교실) ;
-
이광윤
(영남대학교 의과대학 약리학교실) ;
- 김원준 (영남대학교 의과대학 약리학교실)
- Jang, Myeong-Soo (Department of Pharmacology College of Medicine, Yeungnam University) ;
- Choi, Eun-Me (Department of Pharmacology College of Medicine, Yeungnam University) ;
-
Ha, Jeoung-Hee
(Department of Pharmacology College of Medicine, Yeungnam University) ;
-
Lee, Kwang-Youn
(Department of Pharmacology College of Medicine, Yeungnam University) ;
- Kim, Won-Joon (Department of Pharmacology College of Medicine, Yeungnam University)
- 발행 : 1994.12.30
초록
흰쥐의 적출 배뇨근에 대한 수종의 potassium 통로개방제의 작용을 관찰하고, 배뇨근에 존재하는 potassium 통로의 특성을 알아보기 위하여 체중 250~350g의 흰쥐 (Sprague-Dawley)를 단두하여 희생시킨 후 방광을 적출하였다. 적출된 방광으로 부터
The purpose of this study was to investigate the characteristics or the potassium channels existing in the rat urinary bladders. Smooth muscle strips of rat detrusor urinae were examined by isometric myography. Relaxation responses of detrusor muscle strips to the three potassium channel openers pinacidil, a cyanoguanidine derivative, BRL 38227, a benzopyran derivative and RP 52891, a tertrahydrothiopyran derivative were examined. The potassium channel openers reduced the basal tone, and the rank order of potency was RP 52891>pincidil>BRL 38227. Procaine, an inhibitor of the voltage-sensitive potassium channel tended to increase the basal tone, but it did not affect the relaxant effects of the calcium-activated potassium channel opener did not antagonize the relaxant effects, but it reduced the Emax of RP 52891 and BRL 38227. Glibenclamide, an inhibitor of the ATP-sensitive potassium channel, antagonized the relaxant effects of pinacidil, RP 52891 and BRL 38227 reducing the Emax of RP 52891 and BRl 38227. Galanin which inhibits secretion of insulin through opening the ATP-sensitive potassium channels in pancreatic