Journal of Yeungnam Medical Science
- 제11권2호
- /
- Pages.262-269
- /
- 1994
- /
- 2799-8010(eISSN)
Cisplatin 투여 후 백서의 간 및 신장에서 Glutathione 대사의 변화
The Change of Glutathione Metabolism in Liver and Kidney of Cisplatin treated Rats
- Kim, Seong-Yong (Department of Biochemistry College of Medicine, Yeungnam University) ;
- Chung, Jae-Yong (Department of Biochemistry College of Medicine, Yeungnam University) ;
- Kim, Jae-Ryong (Department of Biochemistry College of Medicine, Yeungnam University) ;
- Kim, Jung-Hye (Department of Biochemistry College of Medicine, Yeungnam University)
- 발행 : 1994.12.30
초록
Cisplatin을 투여한 흰쥐의 간장 및 신장에서GSH의 역할을 관찰하고자 총 GSH의 농도, GSH peroxidase 및 GSH reductase이 효소활성도를 관찰하여 다음과 같은 결과를 얻었다. 총 GSH의 양(mM/g protein)은 간에서는 cisplatin을 투여한 군(
Glutathione (GSH) is a well-known antioxidative cellular component which is ubiquitous in nature. Several enzymes involved in GSH metabolism and recycling have been found to play important roles in detoxification of xenobiotics and free radicals. In this study, total GSH content, activity of GSH peroxidase and GSH reductase were measured in liver and kidney of cisplatin treated rats. Total GSH content (mM/g protein) of liver was higher in cisplatin treated rats (