Journal of Yeungnam Medical Science
- Volume 11 Issue 1
- /
- Pages.186-192
- /
- 1994
- /
- 2799-8010(eISSN)
A Case of Amiodarone-induced Interstitial Lung Disease
Amiodarone의 투여로 야기된 간질성 폐 질환의 1례
- Kim, Byeong-Hun (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
-
Park, Jong-Won
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Jung, Jin-Hong (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
-
Lee, Kwan-Ho
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
-
Kim, Young-Jo
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Shim, Bong-Sup (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Hyun-Woo (Department of Internal Medicine, College of Medicine, Yeungnam University)
- 김병훈 (영남대학교 의과대학 내과학교실) ;
-
박종원
(영남대학교 의과대학 내과학교실) ;
- 정진홍 (영남대학교 의과대학 내과학교실) ;
-
이관호
(영남대학교 의과대학 내과학교실) ;
-
김영조
(영남대학교 의과대학 내과학교실) ;
- 심봉섭 (영남대학교 의과대학 내과학교실) ;
- 이현우 (영남대학교 의과대학 내과학교실)
- Published : 1994.06.30
Abstract
Amiodarone has a potent suppressive effect on supraventricular and ventricular dysrhythmias, so has widely used as a class III antiarrhythmic agent. However, significant side effects were noted in over 50% of patients treated. Pulmonary toxicity represents the most serious adverse raeaction limiting the clinical efficacy of this new antidysrhythmic drug. A 66-year-old male had received amiodarone 200mg/day for 7 months to control high grade ventricular premature contraction and was admitted due to dyspnea on exertion for 1 week. At the time of admission end-inspiratory crepitant rale was heard on auscultation. The roentgenogram of his chest revealed reticular and granular radioopaque densities on both lower lung fields and high resonance CT revealed interstitial fibrosis and pneumonic consolidations on the periphery of the both middle and lower lobes. Trans-bronchoscopic lung biopsy revealed nonspecific intersitial fibrosis. The laboratory findings were non-specific. We present a case of amiodarone-induced interstitial pulmonary disease clinically improved by cortico-steroid therapy.
저자들은 Lown grade IVa의 심실성 기외 수축으로 진단 받고, amiodarone을 약 7개월간 투여 받은 환자에서 amiodarone으로 야기된 간질성 폐질환의 1례를 경험하였기에 그 휘기성에 비추어 문헌 고찰과 함께 보고하는 바이다.