Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)
- Volume 4 Issue 2
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- Pages.148-156
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- 1994
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- 2384-132X(pISSN)
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- 2289-0564(eISSN)
Studies on Hepatic Microsomal Alcohol Dehydrogenase(ADH) and Aldehyde Dehydrogenase(ALDH) Activities in Rats Treated with Trichloroethylene
Trichloroethylene 처리한 흰쥐의 간 미크로좀 Alcohol dehydrogenase와 Aldehyde dehydrogenase 활성도에 관한 연구
- Kim, Ki-Woong (Industrial Health Research Institute Korea Industrial Safety Corporation) ;
- Kang, Seong Kyu (Industrial Health Research Institute Korea Industrial Safety Corporation) ;
- Yang, Jeong Sun (Industrial Health Research Institute Korea Industrial Safety Corporation) ;
- Park, In-Jeong (Industrial Health Research Institute Korea Industrial Safety Corporation) ;
- Moon, Young-Hahn (Industrial Health Research Institute Korea Industrial Safety Corporation)
- 김기웅 (한국산업안전공단 산업보건연구원) ;
- 강선규 (한국산업안전공단 산업보건연구원) ;
- 양정선 (한국산업안전공단 산업보건연구원) ;
- 박인정 (한국산업안전공단 산업보건연구원) ;
- 문영한 (한국산업안전공단 산업보건연구원)
- Published : 1994.11.30
Abstract
Chloral hydrate(CH), an intermediate metabolite of trichloroethylene(TRI) is reduced to trichloroethanol(TCE-OH), and is oxidized to trichloroacetic acid(TCA) by the nicotinamide adenine dinucleotide(NAD)-dependent enzymes such as alcohol dehydrogenase(ADH) and aldehyde dehydrogenase(ALDH) in liver. This study was performed to find out the change of activity of ADH and ALDH with increasing amount of TRI. Intraperitoneal injection of TRI were done to the male Sprague Dawely rats(mean body weight,
Keywords
- Trichloroethylene;
- Hepatic microsomal cytochrome P-450;
- Liver Alcohol dehydrogenase and Aldehyde dehydrogenase;
- Urinary Total trichloro-compounds