치과방사선 (Journal of Korean Academy of Oral and Maxillofacial Radiology)

대한영상치의학회 (Korean Academy of Oral and Maxillofacial Radiology)
권호 표지

Streptozotocin유도 당뇨병이 백서하악 절단과두 치유에 미치는 영향의 실험적 연구

REMODELING PROCESS OF THE STREPTOZOTOCIN-INDUCED DIABETIC RAT'S RESECTED CONDYLE

  • 김원철 (경희대학교 치과대학 구강악안면방사선학 교실ㆍ구강진단내과학 교실) ;
  • 황의환 (경희대학교 치과대학 구강악안면방사선학 교실ㆍ구강진단내과학 교실) ;
  • 이상래 (경희대학교 치과대학 구강악안면방사선학 교실ㆍ구강진단내과학 교실) ;
  • 홍정표 (경희대학교 치과대학 구강악안면방사선학 교실ㆍ구강진단내과학 교실)
  • Kim Won-Cheol (Dept. of Oral and Maxillofacial Radiology, Oral Diagnosis and Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Hwang Eui-Hwan (Dept. of Oral and Maxillofacial Radiology, Oral Diagnosis and Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Lee Sang-Rae (Dept. of Oral and Maxillofacial Radiology, Oral Diagnosis and Oral Medicine, College of Dentistry, Kyung Hee University) ;
  • Hong Jung-Pyo (Dept. of Oral and Maxillofacial Radiology, Oral Diagnosis and Oral Medicine, College of Dentistry, Kyung Hee University)
  • 발행 : 1994.12.01
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초록

The purpose of this study was to investigate the remodeling process of the streptozotocin-induced diabetic rat's resected condyle. This experiment was performed with male Sprague-Dawly strain rats weighing approximately 250 gm, which were rendered diabetic by an intravenous injection of streptozotocin(70㎎/㎏ body weight). After condylectomy, experimental rats were serially terminated on the 1st week, the 2nd week, the 3rd week, and the 4th week. The following termination, the mandibles were dissected out to make specimens. Each mandibular condyle was radiographed with Hitex HA-80(Hitex Co., Ltd. Japan). In addition to radiographic observation, the mandibular condyles, further decalcified and embedded in paraffin, were sectioned and stained with Hematoxylin and Eosin, Toluidine blue and Masson's trichrome. They were observed with a light microscope and a polarizing microscope. The results were as follows. 1. Soft X-ray radiograms revealed proliferation of bone after 1 week in both groups. Irregularly repaired bones and dense trabeculae were clearly observed in experimental group. 2. The resected condyles were repaired by intramembraneous and endochondral bone formation in both groups. 3. Bone tissue repair was initiated from the adjacent margin of resected bone, and cartilaginous tissues were observed at the top of repaired bone in both groups. 4. The number of osteoblasts of experimental group was small, compared with control group. Each osteoblast was small and flat. The thin trabeculae were irregularly formed. 5. Collagens of bone were gradually matured in both groups, but the degree of maturation was lower in experimental group. 6. Fibrous tissues covered the upper parts of repaired bone were densely arranged in the both groups. Conclusively, atrophied osteoblasts, immature collagen of bone, and thin and irregular trabeculae which were characterized in the diabetes experimental group showed diabetes disturbed osteoblastic function and caused disturbance of remodeling process of bone.

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