The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Syntheis and $^{99m}Tc$ labeling of Ethylcystein Dimer and Its Brain SPECT Image

두뇌 혈류영상용 방사성의약품인 Ethylcystein Dimer(ECD)의 합성과 $^{99m}Tc$ 표지 및 뇌단일광자단층영상 구성

  • Jeong, Jae-Min (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Lee, Myung-Chul (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Chung, Soo-Wook (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Lee, Kyung-Han (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Cho, Jung-Hyuck (Division of Applied Science, Korea Institute of Science and Technology) ;
  • Kwark, Cheol-Eun (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Chung, June-Key (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Koh, Chang-Soon (Department of Nuclear Medicine, Seoul National University Hospital)
  • 정재민 (서울대학교병원 핵의학과) ;
  • 이명철 (서울대학교병원 핵의학과) ;
  • 정수욱 (서울대학교병원 핵의학과) ;
  • 이경한 (서울대학교병원 핵의학과) ;
  • 조정혁 (한국과학기술연구원 응용과학부) ;
  • 곽철은 (서울대학교병원 핵의학과) ;
  • 이동수 (서울대학교병원 핵의학과) ;
  • 정준기 (서울대학교병원 핵의학과) ;
  • 고창순 (서울대학교병원 핵의학과)
  • Published : 1994.09.15
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Abstract

Ethylcystein dimer (ECD) was synthesized by dimerizatlon of L-thiazolidine-4-carboxylic acid in liquid ammania with sodium metal and successive esterification in ethanolic solution of hydrogen chlorde. The purified product was labeled with $^{99m}Tc$ in the presence of sodium glucarate(pH= 5.6) and stannous chloride. Best result was obtained from the preparation con sisting of 0.1mg ECD, $40{\mu}l$ of 0.4M sodium glucarate (pH=5.6), and $20{\mu}g$ of stannous chloride. The labeling efficiency was 90% with previous condition. The labeled $^{99m}Tc$-ECD was stable at least for 3 hours in PBS(pH=7.4) at room temperature. About 10mCi of $^{99m}Tc$-ECD was injected to normal volunteer, and SPECT image of brain was obtained by triple head camera 10 minutes after inection. The image showed similar distribution of radioactivity in brain with that of HMPAO image.

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