General Pharmacology of G009, a Polysaccharide Isolated from Ganoderma lucidum IY 009

영지의 단백다당체 G009의 일반약리작용

  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
  • Cheon, Seon-Ah (Natural Products Research Institute, Seoul National University) ;
  • Kim, Sang-Mee (Natural Products Research Institute, Seoul National University) ;
  • Kim, Kyung-Ran (Natural Products Research Institute, Seoul National University) ;
  • Kim, Su-Ung (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Lee, Seung-Yong (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Lee, seung-Mok (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Jeong, Hoon (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Hyun, Ik-Sang (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Lee, June-Woo (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.) ;
  • Han, Man-Deuk (Central Research Laboratory, Il Yang Pharmaceutical Company, Ltd.)
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 천선아 (서울대학교 천연물과학연구소) ;
  • 김상미 (서울대학교 천연물과학연구소) ;
  • 김경란 (서울대학교 천연물과학연구소) ;
  • 김수웅 (일양약품(주) 중앙연구소) ;
  • 이승룡 (일양약품(주) 중앙연구소) ;
  • 이승목 (일양약품(주) 중앙연구소) ;
  • 정훈 (일양약품(주) 중앙연구소) ;
  • 현익상 (일양약품(주) 중앙연구소) ;
  • 이준우 (일양약품(주) 중앙연구소) ;
  • 한만덕 (일양약품(주) 중앙연구소)
  • Published : 1994.12.01

Abstract

A polysaccharide, G009, isolated from Ganoderma lucidum IY 009, was subjected to investigating on general pharmacology. This material at the large oral doses of 1000 and 2000 mg/kg in mice did not exhibit any abnormal behaviors and another effects on central nervous system. It also had no influences on hexobarbital-induced sleeping time, rotarod test and spontaneous activity test at each oral dose of 1000 mg/kg in mice. No effects on the body temperature and on acetic acid induced writhing syndrome in mice were observed with its oral administration at 1000 mg/kg, and the convulsions induced by strychnine and pentetrazole were not inhibited at its oral doses of 1000 mg/kg in mice. The solution of G009 as given intravenously at the doses of 30 and 60 mg/kg in rabbit had no influences on blood pressure and respiration rates and depth. In isolated organs of rat uterus and fundus muscles and guineapig ileum and trachea, it did not show any contraction or relaxation at the concentrations of 2$\times$10$^{-3}$ g/ml, and the contractive actions produced by oxytocin, acetylcholine, serotonin and histamine were not inhibited at the same doses. This material showed no effect on intestinal propulsion test in mice and gastric secretion in rats at the oral doses of 1000 mg/kg. However, it is interesting that the material exhibited potent inhibition of acidified aspirin induced gastric damage at the doses of 500 and 1000 mg/kg in rats.

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