Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Acute toxicity of DA-3030(G-CSF) in rats and mice

랫드와 마우스에서 DA-3030(G-CSF)의 급성독성에 관한 연구

  • 이영순 (서울대학교 수의과대학 공중보건학교실) ;
  • 조재진 (서울대학교 수의과대학 공중보건학교실) ;
  • 김영석 (서울대학교 수의과대학 공중보건학교실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학교실) ;
  • 박재학 (실험동물의학교실) ;
  • 이순복 (동아제약(주)연구소)
  • Published : 1994.11.01
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Abstract

This study was performed to evaluate the acute toxicity of DA-3030(granulocyte-colony stimulating factor, G-CSF) in mice and rats via intragastrical and intravenous routes. DA-3030(G-CSF) in the acute toxicity study did not induce any toxic signs in the mice and rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD$_{50}$ values in mice and rats would be >13, 800 $\mu\textrm{g}$/kg in the oral route and >6, 900 $\mu\textrm{g}$/kg in the intravenous route.e.

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