Biomolecules & Therapeutics
- 제2권2호
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- Pages.173-184
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- 1994
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
간장질환 치료용 의약조성물(DWP 305)의 일반약리작용
General Pharmacology of DWP 305, a New Combined Drug for Hepatic Diseases
초록
The general and some pharmacological actions of DWP 305 were investigated in animals and the following results were obtained. In central nervous system, DWP 305 had no effects on the pentobarbital induced anaesthesia, locomotor activity, rotarod test, traction test, analgesic action in mice and body temperature in rat. DWP 305 showed no depressive action on convulsion induced by strychnine, electronic shock and pentylenetetrazole. From these results, DWP 305 was considered to have no pharmacological effect on the central nervous system. Furthermore, DWP 305 had no influences on the normal blood pressure and heart rate. In the isolated ileum of guinea pig, DWP 305 inhibited contractive effects against the acetylcholine (10
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