흰쥐의 cis-[$Pt(NH_3)_2Cl_2$ 신장독성 회복과 Bacillus subtilis의 증식을 위한 디티오카바메이트의 합성, 성질 및 응용

Synthesis, Properties, and Application of Dithiocarbamate for Rescue of cis-[$Pt(NH_3)_2Cl_2$] Nephrotoxicity in Rats and Growth of Bacillus subtilis

  • 이우식 (경원전문대학 환경공업과) ;
  • 김찬우 (대구대학교 사범대학 화학교육과) ;
  • 김인식 (충주산업대학교 공업화학과) ;
  • 김창수 (대구대학교 사범대학 화학교육과)
  • 발행 : 1994.09.01

초록

Dithiocarbamates containing polar groups which give very water soluble metal complexes were prepared from the reaction of carbon disulfide with diamines. The compounds have been characterized by elemental analysis, molar conductivity, and spectroscopic results. Dithiocarbamate and its complex were soluble in water. N, N-Dimethylammoniumpropylenedithiocarbamate(A) is clearly effective as inhibition of cis-platinum nephrotoxicity in rats. From the result of A rescue after cis-dichlorodiammineplatinum(II) treatment, it is suggested that dithiocarbamate removes platinum(II) coordinated to -SH groups bound to protein of kidney tubule cells by the reaction of platinum(II) with dithiocarbamate injected. A is effective as antidots for acute cadmium poisoning in Bacillus subtills. Growth of Bacillus subtills may be accelerated by A ligand dissociated from cadmium (II)-A complex.

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