Synthesis, Properties, and Application of Dithiocarbamate for Rescue of cis-[$Pt(NH_3)_2Cl_2$] Nephrotoxicity in Rats and Growth of Bacillus subtilis

흰쥐의 cis-[$Pt(NH_3)_2Cl_2$ 신장독성 회복과 Bacillus subtilis의 증식을 위한 디티오카바메이트의 합성, 성질 및 응용

Dithiocarbamates containing polar groups which give very water soluble metal complexes were prepared from the reaction of carbon disulfide with diamines. The compounds have been characterized by elemental analysis, molar conductivity, and spectroscopic results. Dithiocarbamate and its complex were soluble in water. N, N-Dimethylammoniumpropylenedithiocarbamate(A) is clearly effective as inhibition of cis-platinum nephrotoxicity in rats. From the result of A rescue after cis-dichlorodiammineplatinum(II) treatment, it is suggested that dithiocarbamate removes platinum(II) coordinated to -SH groups bound to protein of kidney tubule cells by the reaction of platinum(II) with dithiocarbamate injected. A is effective as antidots for acute cadmium poisoning in Bacillus subtills. Growth of Bacillus subtills may be accelerated by A ligand dissociated from cadmium (II)-A complex.