Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Preparation and Antileukemic Activity of Congeners of Tropoloisoquinoline Alkaloids from Abuta Concolor

  • Hideji Itokawa (Department of Pharmacognosy, Tokyo College of Pharmacy) ;
  • Kouji Matsumoto (Department of Pharmacognosy, Tokyo College of Pharmacy) ;
  • Hiroshi Morita (Department of Pharmacognosy, Tokyo College of Pharmacy) ;
  • Koichi Takeya (Department of Pharmacognosy, Tokyo College of Pharmacy)
  • Published : 1994.05.01
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Abstract

Antileukemic tropoloisoquinoline alkaloids, pareirubine A (1) and gandirubrine (2), at first have been isolated from.Abuta concolor (Menisper-maceae). Methylation of 1 and 2, existing in solution as a mixture of tautomersgave the corresponding four methyl derivatives (3 -6). Thioimerubrine (7) andthioisoimerubrine (8) were prepared by the nucleophilic substitutions of themethoxyl groups at C-11 and -10, respectively. Acetylation of 1 and 2produced the corresponding mono-acetyl tautomers (9 and 10). Antileukemicactivity of these derived tropoloisoquinoline alkaloids is also reported.

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References

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