The Korean Journal of Food And Nutrition (한국식품영양학회지)
- Volume 7 Issue 3
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- Pages.232-238
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- 1994
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- 1225-4339(pISSN)
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- 2287-4992(eISSN)
Effect of Ampelopsis radix on the Toxicity of Adriamycin
Adriamycin의 독성 발현에 미치는 백렴(Ampelopsis radix)의 영향
- Published : 1994.09.01
Abstract
Adriamycin is a major cancer chemotherapeutic agent against a me range of human neoplasms. However, its clinical application is limited since It has a variety of side effects, bone marrow suppression and cardiotoxity, and this toxicity appears by free radical. This study investigated the effect of Ampelopsis radix on the toxicity of adriamycin. The methanol fraction reduced slightly adriamycin induced lipid peroxidation and superoxide production at the dose of 50mg /kg. 1.p., respectively. During the adriamycin administration. Protein bound-SH, nonprotein bound-SH, and glutathione-5-transferase did not change, but methanol fraction treated group were markedly increase. These results indicated that Ampelopsis radix has a major influence on the thiol group and related enzyme activity on the antioxidative effects.
Keywords
- adriamycin;
- Ampelopsis radix;
- chemotherapeutic agent;
- antioxidative action;
- bone marrow suppression;
- cardiotoxidity;
- lipid peroxidation