Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Characteristics of Antitumor Antibiotics HS-1 from a Stveptomyces JIoridiae SHS-1372

Streptomyces floridae SHS-1372가 생산하는 항암항생물질 HS-1의 특성

  • 하상철 (KIST. 유전공학 연구소 생물공학 연구실) ;
  • 홍순덕 (경북대학교 자연과학대학 미생물학과)
  • Published : 1994.04.01
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Abstract

Antitumor antibiotic HS-1 was purified from the culture broth of a streptomyces floridae SHS-1372 which had been isolated from soil, by solvent extraction, silica gel column chromatography and gel filtration. It was confirmed that HS-1 was active against gram positive bacteria and cancer cells(K562, P388, MCF-7, HT-29). Through the analysis of UV spectrum, melting point, IR spectrum, FAB-MS, $_{1}$H-NMR, $_{13}$C-NMR, 2D-NMR spectra, HS-1 could be identified sa the actinomycin X$_{2}$ antibiotics containing actinocine chromophore and peptides consisted of threonine, proline, methylvaline, sarcosine, D-valine and 4-ketoproline.

Keywords

References

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