한국동물학회지 (The Korean Journal of Zoology)
- 제37권4호
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- Pages.592-596
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- 1994
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- 0440-2510(pISSN)
단핵구 분화에 있어서 Fibronectin 수용체의 역할
A Functional Role of Fibronectin Receptors in the Monocyte Differentiation
초록
The interaction between fibronectin (FN) and its receptors controls cell attachment and migration, two crucial events during monocyte development and differentiation. To investigate the functional role of FN and its receptor, we have studied adhesion of monocyte to two different regions of FN (38- and 85-kDa domain), as well as the expression of the integrin during monocle differentiation. Anti-integrin Rl subunit antibody completely blocked the attachment of FN-coated latex beads to macrophage, but the effect of anti-integrin u4 antibody was much less significant. Rat monocyte expressed integrin