Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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5-Substituted Pyrimidine Acyclis Nucleoside Analogues 1-Cyanomethyl- and 1-(4-Cyanobutyl)-5-substituted Uracils as Candidate Antitumor Agents

  • Kim, Jack-C. (Department of Chemistry, College of Natural Science) ;
  • Dong, Eun-Soo (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Park, Jin-Il (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Bae, Sang-Duk (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Kim, Seon-Hee (Department of Biochemistry, College of Medicine, Pusan University)
  • Published : 1994.12.01
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Abstract

A number of 5-substituted pyrimidine acyclic nucleosides were synthesized and tested for invitor cytotoxicity against four cell lines (j-82 cell, p-388 cell, FM-3A cell and U-938 cell lines). Synthesis of 1-cyanomethyl-5-substituted pyrimidines (1a-e) and 1-(4-cyanobutyl)-5-substituted pyrimidines (2a-e) was acomplished from the series of alkylation reactions ofl 5-substituted uracils with the corresponding chloacetonitrile and 5-chlorovaleronitile in DMSO under $50^{\circ}C$ temperature. These 5-substituted pyrimidine acylic nucleosides (1a-e and 2a-e) exhibited moderate to significant acitivity aginst four cell lines.

Keywords

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