Archives of Pharmacal Research
- 제17권4호
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- Pages.263-268
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
In vivo Pharmacological Evaluation of Newly Synthesized Nonpeptidic $AT_1$ Receptor Antagonists in Rats
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Lee, Byung-Ho
(Screening and Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
- Shin, Hwa-Sup (Screening and Toxicology Research Center, Korea Research Institute of Chemical Technology)
- 발행 : 1994.08.01
초록
This study was conducted to characterize the in vivo pharmacology of KR-30988, KR-30992 and losartan, new AT antagonists, given as i.v. cumulative doses, in two antimal models of high renin, conscious renal artery-ligated hypertensinve rats (RHRs) and nomotensive rats anesthetized with urethane (90 mg/kg, i.p.) and .alpha.-chloralose (90 mg/kg, i.p.), with a special emphasis on the phamacological characterization of the latter model. In conscious RHRs, KR-30988, KR-30992, losartan and captopril caused a dose-dependent decrease in blood pressure, their relative potencise (