Archives of Pharmacal Research
- 제17권4호
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- Pages.213-217
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- 1994
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Testicular Degeneration and Sperm Loss Induced by Chronic Administration of CocaineiIn Mice
- Suh, Jeong-Hye (College of Pharmacy, Kangwon National University) ;
- Yang, Boo-Keun (College of Animal Agriculture Kangweon National University and Korea Institute of Drug Abuse, Chuncheon) ;
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Lim, Dong-Koo
(College of Pharmacy Chonnam National University) ;
- Jhoo, Wang-Kee (College of Pharmacy, Kangwon National University) ;
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Kim, Hyoung-chun
(College of Pharmacy, Kangwon National University)
- 발행 : 1994.08.01
초록
The effect of ccocaine on reproductive system were studied in male ICR mice. daily injection of cocaine HCL (10, and 40 mg/kg s.c for 15 days) disrupted epididymal sperm levels and testicular morphology. These disruptions were manifested in a decreased number of sperum, an increased number of dead sperm as compared with control vehicle, and wre evidenced by vacuolations, multinucleated giant cell formations and coagulation necrosis in the testicular seminiferous tubules. Responses in the current study were trended in dose dependent pattem. These results suggest that thronic cocaine intoxication can perturb on male reproductive organ functioning.
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