Reduced Anti-inflammatory Activity of Acetylsalicylic Acid Maltol Ester, Aspalatone

  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Suh, Dae-Yeon (Natural Products Research Institute, Seoul National University) ;
  • Yang, Hyun-Ok (Natural Products Research Institute, Seoul National University) ;
  • Lee, Song-Jin (College of Pharmacy, Kangweon National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangweon National University)
  • Published : 1994.06.01

Abstract

The anti-inflammatory activity of acetylsalicylic acid maltol ester (aspalatone), a potential anti-thombotic agent, was studied using the several experimental animal models of inflammation. By oral administration, aspalatone was found to possess the weak anti-inflammatory activity in models of an acute inflammation, in which aspalatone showed approximately one-third to one-fourth of the anti-inflammatory activity of aspirin. Aspalatone (200 mg/kg/day) and aspirin (50 mg/kg/day), however, did not show the inhibitory activity against granuloma fomation and adjuvant-induced arthritis.

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