Archives of Pharmacal Research
- Volume 17 Issue 2
- /
- Pages.119-123
- /
- 1994
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis of Antithypertensive Agents via Couping Reaction of Benzothiazepinone and 1,4-Dihydropyridine Derivatives
-
Ham, Won-Hun
(College of Pharmacy, Sungkyunkwan University)
;
- Yang, Jae-Gwon (College of Pharmacy, Sungkyunkwan University) ;
- Lim, Tae-Gyun (College of Pharmacy, Sungkyunkwan University) ;
- Jung, Yun-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Chung, Yun-Sung (College of Pharmacy, Sungkyunkwan University)
- Published : 1994.04.01
Abstract
The synthesis of 3a, 3b, 7a fro Benzpthiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone nad 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothize-pinone nad 1,4-dihydropyridine derivatives.