Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Effect of Sodium Taurodihydrofusidate on Nasal Drug Delivery: Differences in Its Concentration and Penetrant Molecular Weight

  • Hosoya, Ken-ichi (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences) ;
  • Kubo, Hiroyuki (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences) ;
  • Takashi-Akutsu (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences) ;
  • Hideshi-Natsume (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences) ;
  • Kenji-Sugibayashi (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences and Life Science Research Center, Josai University) ;
  • Yasunori-Morimoto (Department of Pharmaceutics, Faculty of Pharmcaceutical Sciences and Life Science Research Center, Josai University)
  • Published : 1994.04.01
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Abstract

The effect of sodium taurodihydrofusidate (STDHF) on drug permeation across nasal mucosa was studied in vitro using Ussing type diffusion chamber. Disodium cromoglicate (DSCG, M.W.5123) and fluorescein isothiocyanate-dextran (FD) of different molecular wieghts (M.W. 4400-71200) were used as model drugs. Pemeation profiles of DSCG and FDs showed a typical pseudo steady-state curve with short lag time. The pemeability coefficient of FD (M.W. 9400) sigmodially increased with increasing STDHF concentration. It also enhanced the DSCG pemeation. Interestingly the enhancement efficacy was independent of molecular weight of penetrants.

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