Antiinflammatory Activity of Isoflavonoids from Pueraria Radix and Biochanin A Derivatives

  • Lee, Song-Jin (College of Pharmacy, Kangweon National University) ;
  • Baek, Ho-Jin (Dept. Chemistry, Kangweon National University) ;
  • Lee, Chang-Hee (Dept. Chemistry, Kangweon National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangweon National University)
  • Published : 1994.02.01

Abstract

For comparing with flavones/flavonols, isoflavonoids isolated from Pueraria radix and chemically synthesized from biochanin A were evaluated for the antiinflammatory activity using mouse ear edema test, Isoflavonoids such as daildzein and puerarin hsowed the significant antiinflammatory activity at a dose of 2 mg/mouse, although their activity was generally less than that of flavones/flavonols. 7-O-Substitution of biochanin A was not facorable for the antiinflammatory activity.

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