가미청간탕(加味淸肝湯)의 효능(效能)에 관(關)한 실험적(實驗的) 연구(硏究)

An experimental research of the effect of Gamichunggantang

  • 홍상훈 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
  • 우홍정 (경희대학교 한의과대학 간계내과학교실) ;
  • 김병운 (경희대학교 한의과대학 간계내과학교실)
  • Hong, Sang-Hun (Dept. of Oriental Internal Medicine, college of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jang-Hun (Dept. of Oriental Internal Medicine, college of Oriental Medicine, Kyung Hee University) ;
  • Woo, Hong-Jung (Dept. of Oriental Internal Medicine, college of Oriental Medicine, Kyung Hee University) ;
  • Kim, Byung-Woon (Dept. of Oriental Internal Medicine, college of Oriental Medicine, Kyung Hee University)
  • 발행 : 1994.10.23

초록

This study was performed to evaluate the effect of the Gamichunggantang on recovering from liver injury induced by d-galactosamine and ${\alpha}$-naphthylisothiocyanate. and following results were obtained. 1. The increases of the serum GOT. GPT activities in mice induced by d-galactosamine and ${\alpha}$-naphthylisothiocyanate were inhibited significantly by the administration of the Gamichunggantang. 2. The increases of the total cholesterol. triglyceride and blood urea nitrogen levels in mice induced by d-galactosamine and ${\alpha}$-naphthylisothiocyanate were significantly inhibited by the administration of the Gamichunggantang. 3. The increase of the ALP activity in mice following liver injury induced by d-galactosamine and ${\alpha}$-naphthylisothiocyanate were inhibited to an extend. but it was not significant. 4. It is considered that the efficacy of the Gamichunggantang on liver cell injury depends on its concentration rate.

키워드

참고문헌

  1. 肝系內科學 金秉雲(外)
  2. 漢藥臨床應用 李尙仁(外)
  3. 대한약전외한약(생약)규격집주해서 지형준;이상인
  4. 慶熙大學校博士學位論文 柴胡淸肝湯이 $CCl_4$中毒白鼠의 肝損傷에 미치는 影響에 關하여 金德鎬
  5. 慶熙大學校碩士學論文 肝臟疾患에 對한 實驗的 및 臨床的 硏究 金炳三
  6. 東洋醫學 v.22 生肝健脾湯이 肝臟의 代謝와 再生機能에 미치는 影響 金秉雲(外)
  7. 東洋醫學 v.15 生肝健脾湯을 利用한 慢性肝炎의 治療 金秉雲(外)
  8. 慶熙大學校碩士學位論文 加味對金飮子의 效能에 關한 實驗的 硏究 金榮哲
  9. 서울大學校 生藥硏究所業績集 茵蔯蒿가 흰쥐 肝조직내 $Na^+,\ K^+$ -ATPase活性에 미치는 영향 金柱賢(外)
  10. 慶熙大學校 碩士學位論文 茵蔯四령散이 急性Alcohol. 高脂肪食 및 Galactosamine 中毒白鼠의 肝損傷에 미치는 影響 朴亨圭
  11. 慶熙大學校 博士學位論文 葛花解醒湯이 ETHANOL 中毒 흰쥐의 肝機能에 미치는 影響 禹弘楨
  12. 慶熙漢醫大論文集 v.3 酒傷病에 應用되는 加味對金飮子가 Ethanol로 因한 白鼠의 肝損傷에 미치는 影響 柳基遠(外)
  13. 慶熙大學校 碩士學位論文 生肝湯의 效能에 關한 臨床的 硏究 李普炯
  14. 中藥大辭典 江蘇新醫學院(編)
  15. 黃帝內經素問校釋 山東中醫學院(校釋)
  16. 黃帝內經靈樞釋解 楊維倫(編)
  17. 仲景全書 張仲景
  18. 和劑局方 徽宗
  19. 中國通艱 v.11 no.10 甘草對小鼠肝藥매的影響 譚毓治(外)
  20. 中國中醫雜誌 v.15 no.8 厚朴的硏究和臨床應用 唐泳
  21. 中國中醫雜誌 v.16 no.3 葛根的實驗硏究與臨床應用新進展 唐註(外)
  22. 新中醫 厚朴溫中湯治療病毒性肝炎 沈舒文
  23. 藥學學報 v.28 no.8 甘草類黃동對四氣化碩致小鼠急性 肝損傷的影響 王根生(外)
  24. 中國中醫雜誌 v.16 no.3 乾薑對缺氣和受寒小鼠的影響 張明發(外)
  25. 北京中醫學報 v.16 no.2 中藥 863 對D-氣基半乳糖肝損傷治療作用的形態學 生化學 實驗硏究 張穎(外)
  26. 中國通報 v.10 no.6 葛根化學成分的硏究 陳妙華(外)
  27. 中國通松 v.12 no.9 茯笭多糖抗腫瘤及其有關藥理作用 陳定南(外)
  28. 中國中醫雜誌 v.15 no.6 茵蔯對小鼠肝藥매的影響 賀平(外)
  29. 肝臟 v.19 福本楊平
  30. Clin. Vhe. v.20 Enzymatic determation of total cholesterol Allaln, C.
  31. Prog. Liver Dis. v.4 Decker, K.;Keppler, D.
  32. J. Clin. Path. v.13 Arapid and precise method for the determination of urea Fawcett, J.K.;Scott, J.E.
  33. YAKUGAKU SASSHI v.105 no.2 Antihepatotoxic activities of crude drugs Hikino, H.
  34. J. Pharm. Soc. Korea. v.10 Han, D.Y.
  35. Pharmacol. Rev. Phy-siol. Biochem. Galactosamin hepatitis : key role of the nucleotide deficiency periiold in the pathogenesis of cell injury and cell death Decker, K.;Keppler, D.
  36. Eur. J. Biochem. v.17 Keppler, D.;Rudigier, J.;Bishoff, E.;Decker, K.
  37. J. Clin. Path. v.7 Kind, P.R.N.;King, E.J.
  38. YAKUGAKU ZASSHI v.111 no.3 Protective effects of various methanol extract of crude drugs on experimental hepatic injury induced by $\alpha$-na-phthylisothiocyanate in rats Kumazawa, N.; Otha, S.; TU, S.;Kamo-gawa, A.;Shinoda, M.
  39. J. Korea Res. Inst. Liv. v.25 Pae, Y.S.;Hong, Y.S.
  40. Am. J. Clin. Phathol. v.28 A colorimetric method for the determination of serum glutamic oxalocacetic acid and glutamic pyruvic transaminase Reitman, S.;Framkel, S.
  41. YAKUGAKU v.102 no.6 Pharmacological studies on Schzandra Fruits.II. Maeda, S.;Sudo, K.;Miyamoto, Y.;Takeda, S.;Shinbo, M.;Aburada, M.;Ikeya, Y.; Taguchi, H.;Harada, M.
  42. YAKUGAKU ZASSHI v.113 no.3 Protective effects of Yaiwan crude drugs on experimental liver injuries Ohta, S.;SAto, N.;Tu, S.;Shinoda, M.
  43. Clin. Chem. v.14 The determation of triglycerides in plasma and tissues Sardesa, V.M.;Mannig, J.A.
  44. J. Lab. and Clin. Med. v.50 Micromethod for the determatin of serum triglyceride Van Handel E.;Zilversmit D.B.
  45. Chem. Pharm. Bull. v.30 no.9 Protective action of Desoxypodophynotoxin on d-galactosamine-induced liver lesion in rats Kiso, Y.;Konno, C.;Hikino, H.;Hashimoto, I.;Wakasa, H.
  46. J. Nat. Prod. v.46 Assay method for anti-hepatotox-ic activity using galactosamin-in-duced cytotoxicity in primary-cul-tured hepatocytes Kiso, Y.;Tohkin, M.;Hikino, H.
  47. Korea Res. Inst. Liv. v.25 Yamahara, J.;Matsuda, H.(et al.)