Journal of Pharmaceutical Investigation
- Volume 24 Issue 4
- /
- Pages.273-279
- /
- 1994
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Stability of Mono- and Bis-pyridinium Oximes in Aqueous Systems
Monopyridinium Oxime과 Bispyridinium Oxime 화합물의 수용액 중 안정성 연구
- Jung, Chang-Hee (Agency for Defense Development) ;
- Choi, Seung-Ju (Agency for Defense Development) ;
- Seo, Won-Jun (Agency for Defense Development) ;
-
Sok, Dai-Eun
(Agency for Defense Development)
- Published : 1994.12.20
Abstract
The stability of three oximes, Hl-6 [(4-carbamoyl-2'[(hydroxyimino)-methyl]- 1,1'-oxydimethylenedi-(pyridinium chloride)], Hl-CN [(4 cyano-2'-[(hydroxyimino)-methyl] -1,1'-oxydimethylene-di-(pyridinium chloride)], and 2-PAM [pralidoxime chloride] in aqueous solutions was evaluated by HPLC assay. The rate of degradation is dependent on the pH as well as the temperature at which the solution is stored. The optimum pH for the stability of these oximes was pH 2 to 3. The degradation rate constant for 2-PAM (