Journal of Pharmaceutical Investigation
- 제24권1호
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- Pages.33-40
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- 1994
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Nitroxynil과 Levamisole의 피하 주사용 복합제제의 설계에 관한 연구
A Formulation Study on the Combined Preparation of Nitroxynil and Levamisole for Subcutaneous Injection
- Oh, Soon-Gyun (College of Pharmacy, Seoul National University) ;
- Oh, Kyoung-Hee (College of Pharmacy, Seoul National University) ;
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University)
- 발행 : 1994.03.20
초록
In order to develop a broad-spectrum veterinary anthelmintic, a combined preparation of nitroxynil and levamisole was formulated for subcutaneous injection. The preformulation studies on solubilization, physicochemical stability and toxicity of combined preparation were performed. The combined preparation of nitroxynil-N-ethylglucamine and levamisole base could be solubilized up to 50.3%(w/v) of active ingredient concentration in propylene glycol/water system. Injectable solutions were most stable at
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