Korean Journal of Pharmacognosy (생약학회지)
- Volume 25 Issue 3
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- Pages.221-225
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- 1994
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Pharmacological Activities of Sesquiterpenes from the Rhizomes of Curcuma zedoaria
아출(莪朮)의 Sesquiterpene 성분의 약물활성
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
- Yoon, Ki-Young (Natural Products Research Institute, Seoul National University) ;
- Cho, Tae-Soon (College of Pharmacy, Sung Kyun Kwan University)
- Published : 1994.09.30
Abstract
Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.
Keywords
- Curcuma zedoaria;
- sesquiterpenes;
- curzerenone;
- curcumenol;
- gastric lesion;
- analgesic action;
- sedative action