Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Flavonoids from Scutellariae Radix on Cataract Formation and Polyol Accumulation in Rat Lens

황금의 Flavonoid 성분들이 Rat 수정체의 백내장 형성과 Polyol 축적에 미치는 효과

  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Chae, Yun-Jung (Natural Products Research Institute, Seoul National University) ;
  • Chung, Myung-Sook (Natural Products Research Institute, Seoul National University) ;
  • Lee, Hee-Ju (College of Pharmacy, Duk Sung Women's University)
  • 신국현 (서울대학교 천연물과학연구소) ;
  • 채윤정 (서울대학교 천연물과학연구소) ;
  • 정명숙 (서울대학교 천연물과학연구소) ;
  • 이희주 (덕성여자대학교 약학대학)
  • Published : 1994.03.30
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Abstract

The ether, ethylacetate and n-butanol soluble fractions from the roots of Scutellaria baicalensis showed a significant inhibition of lens aldose reductase (AR) activity in vitro. During systematic fractionation of the active fractions, 7 flavonoids were isolated and compared their inhibitory activities against rat AR using DL-glyceraldehyde as a substrate, among which baicalin (VII) was found to exhibit the most potent inhibitory activity. Baicalin (VII) and wogonin-7-O-glucuronide (VI), with repeated treatments (30 mg/kg/day, i.p.) throughout the experimental periods caused a significant suppression of cataract formation induced by galactose (40 g/kg/day) as well as the decrease of galactitol accumulation in the rat lens. The flavonoids also exhibited a significant inhibition of sorbitol accumulation in the lenses of diabetic rats induced by streptozotocin (STZ).

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