The Korean Journal of Pharmacology (대한약리학회지)
- Volume 30 Issue 3
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- Pages.299-311
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- 1994
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- 0377-9459(pISSN)
The Mode of Action of Pentazocine on Catecholamine Secretion from the Perfused Rat Adrenal Medulla
흰쥐 관류부신에서 Pentazocine의 카테콜아민 분비작용의 기전
- Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University) ;
- Kim, Bong-Han (Department of Pharmacology, College of Medicine, Chosun University) ;
- Heo, Jae-Bong (Department of Pharmacology, College of Medicine, Chosun University) ;
- Choi, Cheo-Hee (Department of Pharmacology, College of Medicine, Chosun University) ;
- Kim, Jin-Ho (Department of Pharmacology, College of Medicine, Chosun University) ;
- Jang, Young (Department of Pharmacology, College of Medicine, Chosun University) ;
- Lee, Jae-Joon (Department of Pharmacology, College of Medicine, Chosun University)
- 임동윤 (조선대학교 의과대학 약리학교실) ;
- 김봉한 (조선대학교 의과대학 약리학교실) ;
- 허재봉 (조선대학교 의과대학 약리학교실) ;
- 최철희 (조선대학교 의과대학 약리학교실) ;
- 김진호 (조선대학교 의과대학 약리학교실) ;
- 장영 (조선대학교 의과대학 약리학교실) ;
- 이재준 (조선대학교 의과대학 약리학교실)
- Published : 1994.12.30
Abstract
The present study was attempted to investigate whether pentazocine, which is known to possess both opioid agonistic and antagonistic properties, produces catecholamines (CA) secretion from the isolated perfused rat adrenal gland, and to establish the mechanism of its action, and also to compare its action with that of some opioids. Pentazocine (30 to 300 ug) injected into an adrenal vein caused a dose-dependent secretory response of CA from the rat adrenal medulla. The pentazocine-evoked secretion of CA was remarkably diminished by the preloading with chlorisondamine
Pentazocine은 opioid 수용체에 대한 흥분작용과 길항작용을 겸유한 opioid계 약물로 알려져 있다. 본 연구에서 흰쥐 적출 관류부신으로 부터 pentazocine의 catecholamine(CA) 분비작용을 관찰하여 그 기전을 규명하고 또한 다른 opioid의 작용과 비교하여 얻어진 결과는 다음과 같다. Pentazocine