YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Study of Cyclophosphamide Metabolite $^{15}N-Isophosphamide$ Mustard

항암제인 Cyclophosphamide의 중간체인 $^{15}N-Isophosphoramide$ Mustard에 관한 연구

  • Koo, Kyo-Im (Department of Food and Nutrition, Hanyang University) ;
  • Ryem, Kon (Department of Microbiology, DanKook University)
  • 구교임 (한양대학교 식품영양학과) ;
  • 염곤 (단국대학교 미생물학과)
  • Published : 1994.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The each nitrogen site of ifosfamide metabolite isophosphoramide mustard was synthesized with isotope enriched nitrogen. $Gylcine-^{15}N$ was converted to $2-chloroethylamine-^{15}N$ hydrochloride which was then reacted with phenyl dichlorophosphate to provide $N,N'-bis(2-chloroethyl)phosphordiamidic-^{15}N_2$ acid phenylester(50%, $PhO(O)^{15}N(CH_2CH_2Cl_2)$. Catalytic hydrogenation of this phenyl ester followed by the addition of cyclohexylamine (CHA) provided $IPM-^{15}N$ as the CHA salt(70%).

Keywords