약학회지 (YAKHAK HOEJI)
- 제38권6호
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- Pages.664-672
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
혼성 Bivalent Ligand 퀴놀론 유도체의 합성
Synthesis of Hybrid Bivalent Ligand Quinolone Derivatives
- Lee, Sang-Pil (College of pharmacy, Chung Ang University) ;
- Im, Chae-Uk (College of pharmacy, Chung Ang University) ;
- Kim, Dong-Soon (College of pharmacy, Chung Ang University) ;
- Yim, Chul-Bu (College of pharmacy, Chung Ang University)
- 발행 : 1994.12.30
초록
Eighteen new hybrid bivalent ligand quinolones that contain two different type of pharmacophores in a single molecule were prepared and evaluated for in viかo antibacterial activity. Hybrid bivalent ligands p-nitrobenzyloxycarbonyl quinolones were prepared by the treatment of active esters of succinyl fluoroquinolones with 1,7-disubstituted fluoroquinolone carboxylic acids in DMF. Eighteen final quinolone carboxylic acids were obtained by the reduction of compounds
키워드
- hybrid bivalent ligand quinolones;
- dual mode of action;
- active esters of N-succinylf-luoroquinolone;
- antibacterial activity;
- 1-[1-[3-carboxy-1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinolinyl]-3S-(-)-3-pyrrolidinyl-amino]-4-[1-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-4-quinolinyl]-4-piperazinyl]-1,4-butandione;