약학회지 (YAKHAK HOEJI)
- 제38권5호
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- Pages.579-585
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
키틴과 파추출액 반응물의 항암 작용
Antitumor Activity of Reaction Mixture of Chitin and Green Onion Extract
-
김영식
(서울대학교 천연물과학연구소) ;
- 박경신 (서울대학교 천연물과학연구소) ;
-
장일무
(서울대학교 천연물과학연구소) ;
-
현진원
(서울대학교 의과대학) ;
- 박재갑 (서울대학교 의과대학) ;
- 박호군 (한국과학기술연구원)
-
Kim, Yeong-Shik
(Natural Products Research Institute, Seoul National University) ;
- Park, Kyung-Shin (Natural Products Research Institute, Seoul National University) ;
-
Chang, Il-Moo
(Natural Products Research Institute, Seoul National University) ;
-
Hyun, Jin-Won
(Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
- Park, Jae-Gahb (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
- Park, Ho-Koon (Korea Institute Science and Technology)
- 발행 : 1994.10.30
초록
Antitumor activity was tested by administration of reaction mixture of green onion extract and chitin to mice bearing sarcoma-180 cells. An intraperitoneal injection of mixture(20 mg/kg/day) to mice Have an 52% inhibition of tumor growth. Inhibition of tumor growth was found to be dose-dependent. When eighty miligrams of the mixture were administered, the weight of tumor was reduced significantly. HPLC analysis indicated the mixture was composed of N-acetyl-D-glucosamine, N-acetylchitobiose and N-acetylchitotriose.