YAKHAK HOEJI (약학회지)
- Volume 38 Issue 5
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- Pages.579-585
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Antitumor Activity of Reaction Mixture of Chitin and Green Onion Extract
키틴과 파추출액 반응물의 항암 작용
- Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
- Park, Kyung-Shin (Natural Products Research Institute, Seoul National University) ;
- Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
- Hyun, Jin-Won (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
- Park, Jae-Gahb (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
- Park, Ho-Koon (Korea Institute Science and Technology)
- 김영식 (서울대학교 천연물과학연구소) ;
- 박경신 (서울대학교 천연물과학연구소) ;
- 장일무 (서울대학교 천연물과학연구소) ;
- 현진원 (서울대학교 의과대학) ;
- 박재갑 (서울대학교 의과대학) ;
- 박호군 (한국과학기술연구원)
- Published : 1994.10.30
Abstract
Antitumor activity was tested by administration of reaction mixture of green onion extract and chitin to mice bearing sarcoma-180 cells. An intraperitoneal injection of mixture(20 mg/kg/day) to mice Have an 52% inhibition of tumor growth. Inhibition of tumor growth was found to be dose-dependent. When eighty miligrams of the mixture were administered, the weight of tumor was reduced significantly. HPLC analysis indicated the mixture was composed of N-acetyl-D-glucosamine, N-acetylchitobiose and N-acetylchitotriose.
Keywords