약학회지 (YAKHAK HOEJI)
- 제38권4호
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- Pages.430-439
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
췌조직과 성장 발육에 따른 흰쥐 조직내 S-Adenosylmethionine Synthetase 활성도 및 S-Adenosyl-L-methionine의 분포
Distribution of S-Adenosylmethionine Synthetase in the Pancreatic Tissues of Various Animals and Changes of S-Adenosylmethionine Synthetase Activities and S-Adenosylmethionine in the Developing Rat Organs
- Park, Seung-Hee (Department of Pharmacy, College of Pharmacy, Sungkyunkwan University) ;
- Yu, Tae-Moo (Department of Standardization of Herbal Drugs, National Institute of Health) ;
- Hong, Sung-Youl (Department of Genetic Engineering, College of Life Science and Natural Resources Sungkyunkwan University) ;
- Lee, Hyang-Woo (Department of Pharmacy, College of Pharmacy, Sungkyunkwan University)
- 발행 : 1994.08.30
초록
S-Adenosyl-L-methionine synthetase (ATP: methionine S-Adenosyltransferase, EC 2.5.1.6; AdoMet synthetase) catalyzes the biosynthesis of S-Adenosyl-L-methionine(AdoMet) from methionine in the presence of ATP. To elucidate the role of transmethylation reaction in the pancreatic tissues, we examined AdoMet synthetase and isozyme activities, and AdoMet contents in the various tissues. The activities of AdoMet synthetase marked the highest in the kidney, and the lowest in the testis among the various tissues of rat. Considerable amounts of AdoMet synthetase activities were detected in the pancreatic tissues of various animals except for those of frog. The level of