YAKHAK HOEJI (약학회지)
- Volume 38 Issue 3
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- Pages.345-350
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Analgesic, Anti-inflammatory and Antiviral Effects of Melandrin Derivatives
Melandrin유도체의 진통 소염 및 항바이러스 효과
- Lim, Jung-Ki (College of Pharmacy, Sung Kyun Kwan University) ;
- Lee, Eun-Bang (Natural Products Research Institute, Seoul National University) ;
- Woo, Won-Sik (Natural Products Research Institute, Seoul National University) ;
- Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University) ;
- Lee, Yeong-Sun (Natural Products Research Institute, Seoul National University) ;
- Ma, Eun-Sook (College of Pharmacy, Hyosung Women's University)
- 임증기 (성균관대학교 약학대학) ;
- 이은방 (서울대학교 천연물과학연구소) ;
- 우원식 (서울대학교 천연물과학연구소) ;
- 이강노 (성균관대학교 약학대학) ;
- 이영순 (서울대학교 천연물과학연구소) ;
- 마은숙 (효성여자대학교 약학대학)
- Published : 1994.06.30
Abstract
Fourteen melandrin derivatives(I-XIV) were investigated on analgesic, anti-inflammatory and antiviral activities . Compound I [N-(p-hydroxybenzoyl)-5-hydroxyanthranilic acid methvl ester], Xll [N-(2-phenoxypropionyl)-5-hydroxy anthranilic acid propyl ester and XIV [N-(2-phenoxypropionyl)-5-hydroxyanthranilic acid exhibited analgesic activity in tail pressure and Randall-Selitto method. But no anti-inflammatory activity was shown. Compound I exhibited weak antiviral activity on Herpes simplex virus type I F strain by virus-induced cytopathic effect(CPE) assay and it's selectivity index(Sl) was 8.17.
Keywords
- Melandrin derivatives;
- analgesic activity;
- herpes simplex virus;
- virus-induced cvtopathic (CPE) assay;
- selectivity index(Sl)