YAKHAK HOEJI (약학회지)
- Volume 38 Issue 1
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- Pages.97-101
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Inhibitory Effects of Hydroxybrazilin on the Platelet Phospholipase $A_2$ Activities in Normal and Streptozotocin Induced Diabetic Rats
Streptozotocin 유도 당뇨병 랫드의 혈소판 Phospholipase $A_2$ 활성에 미치는 Hydroxybrazilin의 영향
- Moon, Chang-Hyun (College of Medicine, Ajou University) ;
- Lim, Dong-Soon (College of Medicine, Ajou University) ;
- Cho, Tae-Soon (College of Pharmacy, Sung Kyun Kwan University) ;
- Kim, Ji-Young (College of Pharmacy, Seoul National University)
- Published : 1994.02.28
Abstract
Platelets play a very important role in nomal hemostasis and their functions are more enhanced in various pathogenic states than in normal state. Especially it has been postulated that abnormal platelet and endothelium function might be major factors of microcirculatory disturbance in diabetes mellitus. Hydroxybrazilin, a phenolic constituent of Hematoxylon campechianum has been examined for its inhibitory effect on platelet aggregation. Its antiaggregatory effect might be mediated through the decrease of ATP release from dense granule and those of thromboxane