YAKHAK HOEJI (약학회지)
- Volume 38 Issue 1
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- Pages.67-77
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Transmucosal Delivery of Luteinizing Hormone-Releasing Hormone: Effect of Medium Chain Fatty Acid Salts on Stabilization of LHRH in Mucosal Homogenates in vitro.
황체호르몬 유리호르몬의 경점막 수송: 가토 점막균질액 중에서 중쇄지방산염의 LHRH에 대한 안정화 효과
- Han, Kun (College of Pharmacy, Chungbuk National University) ;
- Park, Jeong-Sook (College of Pharmacy, Chungbuk National University)
- Published : 1994.02.28
Abstract
In order to investigate the feasibility of transmucosal delivery of the model peptide, LHRH, metabolism of LHRH and inhibition effect of medium chain fatty acid salts were studied in rabbit mucosal homogenate. LHRH incubated in homogenates of rectal(RE), nasal(NA) and vaginal(VA) mucosa were assayed by HPLC. Five to six degradation products of LHRH were deterted and the degradation of LHRH