YAKHAK HOEJI (약학회지)
- Volume 38 Issue 1
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- Pages.6-11
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
The Cytotoxic Limonoid From the Fruits of Melia Toosendan
천련자로부터 분리한 Limonoid 성분의 세포독성
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Km, Young-Ho
(KIST, Genetic Engineering Research Institute) ;
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Hwang, Bang-Yeon
(College of Pharmacy, Chungbuk National University) ;
- Kim, Se-Eun (KIST, Genetic Engineering Research Institute) ;
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Kim, Hwan-Mook
(KIST, Genetic Engineering Research Institute) ;
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Oh, Goo-Taeg
(KIST, Genetic Engineering Research Institute) ;
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Ro, Jai-Seup
(College of Pharmacy, Chungbuk National University) ;
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Lee, Kyong-Soon
(College of Pharmacy, Chungbuk National University) ;
- Lee, Jung-Joon (KIST, Genetic Engineering Research Institute)
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김영호
(KIST, 유전공학연구소) ;
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황방연
(충북대학교 약학대학) ;
- 김세은 (KIST, 유전공학연구소) ;
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김환묵
(KIST, 유전공학연구소) ;
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오구택
(KIST, 유전공학연구소) ;
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노재섭
(충북대학교 약학대학) ;
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이경순
(충북대학교 약학대학) ;
- 이정준 (KIST, 유전공학연구소)
- Published : 1994.02.28
Abstract
The MeOH extract of the fruits of Melia toosendan was selected for futher study by its cytotoxicity and effect on the human breast cancer cell line, MCF-7. The active principle obtained by activity guided fractionation followed by purification gave rise to a needle crystal. The structure was deduced by employing NMR and was determined to be identical with 28-deacetyl sendanin by comparison with published data. This compound induced morphological change of MCF-7 to be rounded with tubule at concentrations between