약학회지 (YAKHAK HOEJI)
- 제38권1호
- /
- Pages.6-11
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
천련자로부터 분리한 Limonoid 성분의 세포독성
The Cytotoxic Limonoid From the Fruits of Melia Toosendan
-
김영호
(KIST, 유전공학연구소) ;
-
황방연
(충북대학교 약학대학) ;
- 김세은 (KIST, 유전공학연구소) ;
-
김환묵
(KIST, 유전공학연구소) ;
-
오구택
(KIST, 유전공학연구소) ;
-
노재섭
(충북대학교 약학대학) ;
-
이경순
(충북대학교 약학대학) ;
- 이정준 (KIST, 유전공학연구소)
-
Km, Young-Ho
(KIST, Genetic Engineering Research Institute) ;
-
Hwang, Bang-Yeon
(College of Pharmacy, Chungbuk National University) ;
- Kim, Se-Eun (KIST, Genetic Engineering Research Institute) ;
-
Kim, Hwan-Mook
(KIST, Genetic Engineering Research Institute) ;
-
Oh, Goo-Taeg
(KIST, Genetic Engineering Research Institute) ;
-
Ro, Jai-Seup
(College of Pharmacy, Chungbuk National University) ;
-
Lee, Kyong-Soon
(College of Pharmacy, Chungbuk National University) ;
- Lee, Jung-Joon (KIST, Genetic Engineering Research Institute)
- 발행 : 1994.02.28
초록
The MeOH extract of the fruits of Melia toosendan was selected for futher study by its cytotoxicity and effect on the human breast cancer cell line, MCF-7. The active principle obtained by activity guided fractionation followed by purification gave rise to a needle crystal. The structure was deduced by employing NMR and was determined to be identical with 28-deacetyl sendanin by comparison with published data. This compound induced morphological change of MCF-7 to be rounded with tubule at concentrations between