The Korean Journal of Physiology
- Volume 28 Issue 2
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- Pages.197-202
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- 1994
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- 0300-4015(pISSN)
A Central Pressor Response to Endogenous Nitric Oxide Synthesis Inhibition in Anesthetized Rats
- Moon, Sung-Ho (Department of Physiology, Chosun University Medical School) ;
- Yang, Min-Joon (Department of Physiology, Chosun University Medical School) ;
- Oh, Seung-Ho (Department of Physiology, Chosun University Medical School) ;
- Kim, Mi-Won (Department of Physiology, Chosun University Medical School) ;
- Yoo, Kwang-Jay (Department of Physiology, Chosun University Medical School) ;
- Lee, Jong-Eun (Department of Physiology, Chosun University Medical School) ;
- Jun, Jae-Yeoul (Department of Physiology, Chosun University Medical School) ;
- Yeum, Cheol-Ho (Department of Physiology, Chosun University Medical School) ;
- Yoon, Pyung-Jin (Department of Physiology, Chosun University Medical School)
- Published : 1994.12.01
Abstract
The present study was aimed to determine if endogenous L-arginine-nitric oxide (NO) pathway has central, rather than peripheral, mechanisms in blood pressure regulation. Arterial blood pressure and heart rate responses to acute inhibition of the t-arginine-NO pathway were examined in rats anesthetized with thiopental (50 mg/kg, IP). An intracerebroventricular (ICV) cannula was placed in the left lateral ventricle. The right femoral artery was cannulated to measure arterial blood pressure and the vein to serve as an infusion route.