The Korean Journal of Physiology
- Volume 28 Issue 1
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- Pages.51-59
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- 1994
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- 0300-4015(pISSN)
The Excitatory Mechanism of Substance P in the Antral Circular Muscle of Guinea Pig Stomach
- Jun, Jae-Yeoul (Department of Physiology, Chosun University Medical College) ;
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Kim, Sung-Joon
(Department of Physiology and Biophysics, Seoul National University College of Medicine) ;
- Choi, Youn-Baik (Department of Surgery, Asan Medical Center Ulsan University College of Medicine) ;
- Kim, Ki-Whan (Department of Physiology and Biophysics, Seoul National University College of Medicine)
- Published : 1994.06.30
Abstract
This study was carried out to elucidate the excitatory mechanisms of Substance P in the antral circular muscle, using isometric contraction recording, conventional microelectrode method and whole-cell patch clamp technique. Substance P produced tonic and phasic contractions in a dose-dependent manner and depolarized membrane potential with increased amplitude of slow waves in muscle strips. Voltage-dependent
Keywords
- Slow wave;
- Antral myocytes;
- Substance P;
- Voltage-dependent $Ca^{2+}$ currents;
- $Ca^{2+}$ activated $K^+$ currents