The Korean Journal of Pain
- Volume 6 Issue 2
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- Pages.231-236
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- 1993
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Clinical Efficacy of Transdermal Clonidine (St 155 BS) for Anesthetic Management in Hypertensive Patients
고혈압 환자 마취시 Transdermal Clonidine (St 155 BS)의 임상적 유용성
- Lee, Hyun-Hwa (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Kim, Dong-Ok (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Kim, Keon-Sik (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Choi, Young-Kyoo (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Shin, Ok-Young (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Kwon, Moo-Il (Department of Anesthesiology, Kyung Hee University College of Medicine) ;
- Lee, Doo-Ik (Department of Anesthesiology, Kyung Hee University College of Medicine)
- 이현화 (경희대학교 의과대학 마취과학교실) ;
- 김동옥 (경희대학교 의과대학 마취과학교실) ;
- 김건식 (경희대학교 의과대학 마취과학교실) ;
- 최영규 (경희대학교 의과대학 마취과학교실) ;
- 신옥영 (경희대학교 의과대학 마취과학교실) ;
- 권무일 (경희대학교 의과대학 마취과학교실) ;
- 이두익 (경희대학교 의과대학 마취과학교실)
- Published : 1993.11.20
Abstract
Clonidine, a centrally-acting antihypertensive agent known to reduce central sympathetic outflow and modulate presynaptic transmitter's release, has shown to suppress central noradrenergic hyperactivity induced by immobilization stress in animals, by decreasing the MAC of halothane and the dose of narcotics required to prevent reflex cardiovascular response to noxious stimuli, and to have potent analgesic properties in humans. These characteristics suggest that clonidine might be a useful adjunct to the anesthetic management of patients with preexisting hypertension. Accordingly, we determined the clinical efficacy and safety on analgesia, sedation and hemodynamic stability in the perioperative period. Thirty patients(ASA physical status II-III) with a history of arterial hypertension, scheduled for elective orthopedic surgery were randomly assigned to two groups. We applied CPA-clonidine patch(
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