A study of Succinyl trialanine p-nitroanilide hydrolytic activity in workers exposed to organic solvents

유기용제 취급 근로자들의 Succinyl trialanine p-nitroanilide 가수분해 효소 활성에 관한 연구

To measure the serum succinyl trialanine p-nitroanilide hydrolytic activity as new index of liver function in workers exposed to organic solvents, this study conducted 114 workers in department of shoe-making of shoes factories. The results obtained from this study were as follows : 1. The mean values of serum GOT, GPT, ${\gamma}GT$ in whole workers were $22{\pm}12.32,\;20{\pm}9.05,\;28{\pm}21.35IU/l$, respectively and the mean value of serum STN hydrolytic activity was $0.08{\pm}0.05$. 2. The serum STN hydrolytic activity was significantly higher for male (p<0.05) and there was no difference among the groups of age. 3. There was no difference in the groups by working hours but significant difference in persons who worked over 3 years or were exposed to toluene over 100ppm (p<0.05). 4. The correlation of the exposed dose of toluene and serum GOT, GPT, ${\gamma}GT$ and serum STN hydrolytic activity were statistically significant (r=0.027-0.518). 5. The exposed dose of toluene was most explainable variable and statistically significant among the factors affecting serum STN hydrolytic activity (p<0.05).

유기용제 취급 근로자들의 간기능 장해의 새로운 지표로서 혈청 Succinyl trialanine p-nitroanilide (STN) 가수분해 효소 활성치에 관한 연구가 신발제조업 제화부서에 근무하는 종사자 114명을 대상으로 시행하여 다음과 같은 결과를 얻었다. 1. 전체 대상자의 간기능 검사치인 혈청 GOT, GPT, ${\gamma}GT$의 평균은 $22{\pm}12.32IU/l,\;20{\pm}9.65IU/l,\;28{\pm}21.35IU/l$였고, 혈청 STN 가수분해 효소 활성치는 $0.08{\pm}0.05$였다. 2. 혈청 STN 가수분해 효소 활성치는 남자에서 통계학적으로 유의하게 높았고(P<0.05), 연령군별로는 차이가 없었다. 3. 일일근무시간별 혈청 STN 가수분해 효소 활성치는 차이는 없었으나, 3년이상 근무한 근로자와 100ppm이상의 톨루엔에 노출된 근로자에서는 혈청 STN 가수분해 효소 활성치가 통계학적으로 유의하게 증가하였다(p<0.05). 4. 톨루엔 노출농도와 혈청 GOT, GPT, ${\gamma}GT$ 및 혈청 STN 가수분해 효소 활성치 사이에는 통계학적으로 유의한 상관관계를 나타냈다(p<0.01). 5. 혈청 STN 가수분해 효소 활성치에 영향을 미치는 요소중에서 톨루엔 노출농도가 가장 설명력이 높고, 통계학적으로 유의하였다(P<0.05).