Korean Journal of Veterinary Research (대한수의학회지)
- Volume 33 Issue 1
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- Pages.101-108
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- 1993
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Studies on the effects of immunization against Babesia gibsoni antigen and Theileria sergenti as a non-specific antigen in dog
Babesia gibsoni 항원접종과 Theileria sergenti를 비특이 항원으로 접종한 개의 면역효과에 관한 연구
- Yoon, Chang-mo (Kunsan Nam Middle School) ;
- Lee, Joo-mook (College of Veterinary Medicine, Chonbuk National University) ;
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Chae, Joon-seok
(College of Veterinary Medicine, Chonbuk National University) ;
- Kwon, Oh-deog (College of Veterinary Medicine, Chonbuk National University)
- Received : 1992.08.10
- Published : 1993.01.30
Abstract
To examine the effects of vaccination against Babesia gibsoni(B gibsoni) infection in dogs, 15 normal mixed-breed dogs(5 months to 1 year old) were divided into 3 groups with 5 dogs in each group. One of them was selected as control group(group A) and other were selected as experimental groups(group B and C). The group B was vaccinated with antigen which were mixed 0.2% of formalin treated B gibsoni and sonicated one. The group C was inoculated Theileria sergenti as a non-specific antigen. The results obtained in this experiment were summarized as follows; 1. After first vaccination, antibody titers of group B and C were increased 5 times(1:200) than those of control group(1 : 40). The antibody titers of group C were increased more than that of group B after second vaccination. When challenged with the living protozoa(Babesia gibsoni), the antibody titers of C group were elevated higher than that of B group and maintained steadly. Those were not exceeded over 1 : 5,000 for 4 weeks in all 3 groups. 2. After challenge, the peak time of the parasitemia appeared nearly on the 15th day(12~18 days) in all groups. During this period, the rate of parasitized erythrocytes in control group was