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The Kinetics and Mechanism of the Hydrolysis to Thienyl Chalcone Derivatives

Thienyl Chalcone 유도체의 가수분해 반응메카니즘과 그 반응속도론적 연구

  • 황용현 (명지대학교 화학공학과) ;
  • 이기창 (명지대학교 화학공학과) ;
  • 김진영 (명지대학교 화학공학과)
  • Published : 1993.11.30

Abstract

The hydrolysis reaction kinetics of 2-thienyl chalcone derivatives $[II]{\sim}[V]$ was investigated by ultraviolet spectrophotometery in 20% dioxane-$H_2O$ at $25^{\circ}C$ and the structure of these compounds were ascertained by means of ultraviolet, infrared and NMR spectra. The rate equations which were applied over a wide pH range(pH $1.0{\sim}13.0$) were obtained. The substituent effects on 2-thienyl chalcone derivatives$[II]{\sim}[V]$ were studied, and the hydrolysis were facilitated by electron attracting groups. On the basis of the rate equation, substitutent effect and final product, the plausible hydrolysis reaction mechanism was proposed : At pH $1.0{\sim}9.0$, not relevant to the hydrogen ion concentration, neutral $H_2O$ molecule competitvely attacked on the double bond. By contraries, above pH 9.0, it was proportional to concentration of hydroxide ion.

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