Applied Microscopy
- Volume 23 Issue 1
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- Pages.35-55
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- 1993
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- 2287-5123(pISSN)
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- 2287-4445(eISSN)
Effects of the cis-Dichlorodiammineplatinum on the Fine Structures of the Interalveolar Septum in the Mouse
cis-Dichlorodiammineplatinum (II) 이 생쥐 폐포간중격의 미세구조에 미치는 영향
- Baik, Tai-Kyeoung (Hanyang University) ;
- Kwon, Ik-Seung (Hanyang University) ;
- Kim, Won-Kyu (Hanyang University) ;
- Baik, Doo-Jin (Hanyang University) ;
- Chung, Ho-Sam (Hanyang University) ;
- Lee, Kyu-Sik (Hanyang University)
- 백태경 (한양대학교 의과대학 해부학교실) ;
- 권익승 (한양대학교 의과대학 해부학교실) ;
- 김원규 (한양대학교 의과대학 해부학교실) ;
- 백두진 (한양대학교 의과대학 해부학교실) ;
- 정호삼 (한양대학교 의과대학 해부학교실) ;
- 이규식 (한양대학교 의과대학 해부학교실)
- Published : 1993.06.01
Abstract
cis-Dichlorodiammineplatinum (II) (cis-Platin), a metallic compound, has widely been used as an effective anticancer chemotherapeutic agent. The precise mechanism of action of this agent is still unknown, but it is postulated that cis-Platin may act on the cancer cell like bifunctional alkylating agents. Although this agent is very beneficial to the patients with cervical cancer, germinoma of testis, neuroblastoma and others, it may also damage to the normal cell so that many side effects; severe hemorrhagic enterocolitis, bone marrow depression, renal damage and liver damage will develope. This experiment has been undertaken to pursue the cytotoxic effects of the cis-Platin on the ultrastructures of the interalveolar septum in the mouse lung. A total of 55 healthy male mice of ICR strain were used as experimental animals and divided into 5 mice of normal control group and 50 mice of cis-Platin treated group. The mice of cis-Platin treated group were sacrificed by carotid exsanguination at 6, 12, 24 hours, 3 days and 7 days after intraperitoneal injection of 6.0 mg of cis-Platin (
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