Antitumoral Compound , MCH-201 , an Effector on Proliferation and Morphology of Human Breast Tumor Cell Line, MCF-7

인체유암세포주 MCF-7의 형태변화와 증식에 영향을 주는 항암활성물질, MCH-201

  • Published : 1993.08.01

Abstract

MCH-201 was isolated from the mycelium of Streptomyces sp. Ba16 as a potent effector on proliferation and morphology of human breast tumor cell line, MCF-7. Morphological change could be observed at concentration between 2.5${\mu}$g/ml and 250pg/ml and showed cytotoxic effect at the concentration of more than 5${\mu}$g/ml. This compound also showed inhibitory effect on DNA synthesis of hepatoma cells, Hepa 1c1c7, and strong cytotoxic effect on proliferation of human tumor cell lines, A549 and XF498.

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