The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 27 Issue 1
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- Pages.28-34
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- 1993
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- 1225-6714(pISSN)
Distribution of the Muscarinic Cholinergic Receptors and Characterization in the Brain of Wistar Rats and Spontaneously Hypertensive Rats (SHR Strain) by Digital Autoradiography
Digital Autoradiographic System을 이용한 선천성고혈압에서의 Muscarinic Cholinergic Receptor 분포 및 특성
- Sohn, In (Kangnam General Hospital) ;
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Lee, Myung-Chul
(Department of Nuclear Medicine, Seoul National University Hospital) ;
- Koh, Chang-Soon (Department of Nuclear Medicine, Seoul National University Hospital)
- Published : 1993.06.15
Abstract
Using in vitro autoradiography with a digital autoradiography system and radioreceptor assay, the distribution and the binding characteristics of the muscarinic cholinergic receptors (mAChR) were studied in regions of rat brain. Radioreceptor assay revealed that mAChR could be measured with saturation binding assay in the brain and heart homogenates: No difference in Kd or Bmax of the brain or heart was found between the normal Wistar rats and SHR rats. Specific binding of
Keywords
- Digital autoradiography;
- Muscarinic cholinergic receptor;
- Radioreceptor assay;
- $^3H$- quinuclidinyl bentilate