대한핵의학회지 (The Korean Journal of Nuclear Medicine)

대한핵의학회 (The Korean Society of Nuclear Medicine)
권호 표지

Zipeprol 남용환자에서 뇌 단일광자방출 전산화단층촬영술의 임상적 의의

Clinical Significance of Brain SPECT in Zipeprol Abusers

  • 조대옥 (경희대학교 의과대학 핵의학내과) ;
  • 김재필 (경희대학교 의과대학 핵의학내과) ;
  • 김덕윤 (경희대학교 의과대학 핵의학내과) ;
  • 양형인 (경희대학교 의과대학 핵의학내과) ;
  • 고은미 (경희대학교 의과대학 핵의학내과) ;
  • 김광원 (경희대학교 의과대학 핵의학내과) ;
  • 최영길 (경희대학교 의과대학 핵의학내과)
  • Cho, Dai-Ok (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Kim, Jae-Phil (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Kim, Deog-Yoon (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Yang, Hyung-In (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Koh, Eun-Mi (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Kim, Kwang-Won (Department of Nuclear Medicine, Kyung Hee University, College of Medicine) ;
  • Choi, Young-Kil (Department of Nuclear Medicine, Kyung Hee University, College of Medicine)
  • 발행 : 1993.06.15
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초록

Drug abuse is widespread in worldwide and has been associated with neurologic complication. Zipeprol is one of the drugs which been abused for psychological satisfaction in some adolescents. This agent is non-opioid antitussive agent, which is not legally considered as being capable of creating dependence or abuse liability at therapeutic serum levels. But it has been reported that acute or chronic overdose create neurologic complication such as convulsion as well as dependence. Recently we experienced six zipeprol abusers who admitted due to convulsion and variable neurologic symptoms. The aim of our study was to determine the role of $^{99m}Tc$-HMPAO brain SPECT in those patients. EEG and brain CT showed no abnormal finding, but brain SPECT showed focal or multiple perfusion abnormalities in frontal, parietal, occipital cortex, basal ganglia, thalamus and especially at temporal cortex. These results suggest that brain SPECT may be a useful diagnostic tool to evaluate the cerebral dysfunction infused by zipeprol abuse.

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