대한화학회지 (Journal of the Korean Chemical Society)

  • 제37권9호
  • /
  • Pages.837-844
  • /
  • 1993
  • /
  • 1017-2548(pISSN)
  • /
  • 2234-8530(eISSN)
대한화학회 (Korean Chemical Society)
권호 표지

N-히드록시-${\alpha}$-아미노산 에스테르의 합성

Synthesis of N-Hydroxy-${\alpha}$-Amino Acid Esters

  • 서민효 (서울대학교 자연과학대학 화학과) ;
  • 왕한철 (서울대학교 자연과학대학 화학과) ;
  • 이윤영 (서울대학교 자연과학대학 화학과) ;
  • 구양모 (서울대학교 약학대학 약학과)
  • Seo, Min-Hyo (Department of Chemistry, Seoul National University) ;
  • Wang, Han-Cheol (Department of Chemistry, Seoul National University) ;
  • Lee, Youn-Young (Department of Chemistry, Seoul National University) ;
  • Goo, Yang-Mo (Department of Pharmacy, Seoul National University)
  • 발행 : 1993.09.20
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초록

N-Arylmethylideneglycine N-oxide alkyl esters(1)를 THF 용매내에서 lithium hexamethyldisilazide로 처리한 다음 할로겐화 알킬과 반응시켜 알킬화하고 이를 히드록실아민으로 분해시켜 N-hydroxy-${\alpha}$-amino acid esters(7)를 합성하였다.

N-Arylmethylideneglycine N-oxide alkyl esters(1) were alkylated with alkyl halides in THF using lithium hexamethyldisilazide as a base, followed by hydroxylaminolysis to give N-hydroxy-${\alpha}$-amino acid esters(7).

키워드

참고문헌

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