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Portage Transport of Toxophoric Agent, N-hydroxyalanine, through Oligopeptide Permease in Escherichia coli

  • Hong, Nam-Joo (Department of Applied Microbiology, College of Agriculture, Yeungnam University) ;
  • Park, Yeong-Taek (Department of Applied Microbiology, College of Agriculture, Yeungnam University)
  • 발행 : 1993.12.20

초록

Di-and tri-peptides containing DL-N-hydroxyalanine were prepared. DL-N-Hydroxyalanine was linked, via its primary amino group, to the ${\alpha}$-carbon of glycine residues in dipeptide synthon (L-alanyl(${\alpha}$-DL-N-hydroxyalanyl)DL-glycine) 5, and tripeptide synthon (L-alanyl-L-alanyl(${\alpha}$-DL-N-hydroxyalanyl) DL-glycine) 12. 5 proved to be 19 times more potent than DL-N-hydroxyalanine when tested in vitro for the ability to inhibit the growth of E coli. However, 12 gave comparable potency to DL-N-hydroxyalanine itself.

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참고문헌

  1. Microorganisms and Nitrogen Sources P. Ringrose;J. Payne(ed.)
  2. J. Med. Chem. v.32 C. Gilvarg;J. Taggart;S. Hwang
  3. J. Gen. Microbial. v.114 D. Logan;J. Becker;F. Naider
  4. J. Gen. Microbial. v.121 M. Davies
  5. Bacterial Transport J. Payne;C. Gilvarg;B. Rosen(ed.)
  6. Proc. Natl. Acad. Sci. U.S.A. v.81 W. Kingsbury;J. Boehm;C. Gilvarg
  7. Biochemistry v.28 K. Duncan;W. Faraci;C. Walsh
  8. Nature (London). v.272 K. Allen;F. Atherton;M. Hall;C. Holmes;R. Lambert;P. Ringrose
  9. J. Med. Chem. v.22 A. Steinfeld;F. Naider;J. Becker
  10. J. Med. Chem. v.23 J. Ti;A. Steinfeld;F. Naider;A. Gulumoglu;J. Becker
  11. J. Gen. Microbial. v.94 M. Kenig;E. Vandamme;E. Abraham
  12. Proc. Natl. Acad. Sci. U.S.A. v.81 W. Kingsbury;J. Boehm;D. Perry;C. Gilvarg
  13. J. Med. Chem. v.27 W. Kingsbury;J. Boehm;R. Mehta;C. Gilvarg
  14. J. Med. Chem. v.32 S. Hwang;D. Berges;T. Taggart;C. Gilvarg
  15. FEMS Microbial Lett. v.79 D. A. Shallow;K. J. Barrett;W. Payne
  16. Int. J. Peptide Protein Res. v.37 P. L. Reux;D. Blant;D. M. Lecreulx;J. V. Heijenhort
  17. J. Am. Chem. Soc. v.83 T. Emery;T. Nielands
  18. J. Chem. Soc. G. Snow
  19. Collect. Czech, Chem. Commum. v.29 J. Turhova;O. Mikev;F. Sorm
  20. J. Biol. Chem. v.171 J. Dutcher
  21. Carbohydr. Res. v.46 J. Tronchet;D. E. Mihaly
  22. J. Chem. Soc. Sect. B. v.56 M. Masui;C. Yagima
  23. J. Chem. Soc. E. Boyland;R. Nery
  24. J. Biol. Chem. v.254 L. Cooper;W. Griffith
  25. Pharm. Ther. v.14 F. Neuhaus;W. Hammes
  26. J. Bact. v.91 J. Lynch;F. Neuhaus
  27. Biochemistry. v.3 F. Neuhaus;J. Lynch
  28. Chem. Pharm. Bull. v.34 G. Giichi;K. Kengi;M. Takuichi
  29. Kor. J. Med. Chem. v.1 N. J. Hong;Y. T. Park;S. U. Koock
  30. Antibiotics: An Integrated View G. Lancini;F. Parenti;G. Lancini(ed.)
  31. Current topics in Membranes and Transport v.14 D. M. Mattews;J. W. Payne
  32. Antimicrobial Agents and Chemotherapy. v.24 F. Atherton;M. J. Hall;W. Lloyd;A. V. Lord;S. Ringrose;D. Westmacott
  33. Proceedings of the 3rd American Peptde Symposium Chemistry and Biology of Peptides H. Joshua;C. M. Deber;J. Meienhofer(ed.)
  34. Proc. Natl. Acad. Sci. U.S.A. v.70 M. J. Adams;M. Buehnev;S. Taylor
  35. J. Biol. Chem. v.258 J. C. Boehm;D. Perrg;C. Gilvarg
  36. Int. J. Pept. Protein. Res. v.27 W. D. Kingsburry;J. C. Boehm
  37. J. Bacteriol. v.106 D. Perry;C. Gilvarg
  38. J. Proc. Natl. Acad. Sci. U.S.A. v.70 B. Ames;G. Ames;J. Young;D. Tsuchiya